Clobetasol-Propionate

1. Basic Information

Name: Clobetasol Propionate

CAS: 25122-46-7

Molecular structure:

Molecular Formula: C₂₅H₃₂ClFO₅

Molecular Weight: 466.97

Appearance: White to off-white powder

Specification: USP/EP

2. Pharmacological Properties

Anti-inflammatory Potency: Its anti-inflammatory effect is approximately 112.5 times that of hydrocortisone, 2.3 times that of betamethasone sodium phosphate, and 18.7 times that of fluocinonide, making it one of the highly effective topical glucocorticoids for clinical use.

Mechanism of Action: It rapidly alleviates symptoms such as skin redness, swelling, and itching by inhibiting the release of inflammatory mediators (e.g., prostaglandins, leukotrienes), reducing inflammatory cell infiltration, and constricting capillaries.

Metabolic Pathway: After topical application, it is absorbed through the skin, primarily metabolized in the liver, and excreted via the kidneys.

3. Core Indications

Indications:Suitable for non-infectious inflammatory skin conditions responsive to glucocorticoid therapy, including:

Chronic Eczema: Relieves skin thickening, lichenification, and severe itching.

Psoriasis (Pityriasis Rubra): Controls erythema, scaling, and inflammatory infiltration.

Neurodermatitis: Reduces skin roughness, hypertrophy, and paroxysmal pruritus.

Lichen Planus: Improves purplish-red polygonal flat papules and itching.

Discoid Lupus Erythematosus: Alleviates facial butterfly erythema and skin damage.

Palmoplantar Pustulosis: Reduces sterile pustules and desquamation on palms/soles.

4. Therapeutic Advantages

Rapid Onset: Short-term use can quickly control acute inflammatory symptoms.

Strong Local Action: Direct application to affected areas minimizes systemic absorption risk.

Diverse Dosage Forms: Includes creams, ointments, liniments, etc., to meet the needs of different skin areas.

5. Usage Guidelines and Precautions

Dosage and Administration

Topical Use: Apply a thin layer to the affected area 1-2 times daily, with treatment duration generally not exceeding 2 weeks.

Special Areas: Avoid application to thin-skinned regions such as the face, axillae, and groin to prevent capillary dilation and skin atrophy.

Occlusive Dressing Therapy: Limited to short-term, small-area use (e.g., for refractory plaque psoriasis, duration may be extended to 4 weeks when the affected area is ≤5%-10% of body surface area).

6. Contraindications and Precautions

Contraindications

Patients with hypersensitivity to this product or other glucocorticoids.

Uncontrolled skin infections (e.g., bacterial, fungal, or viral infections).

Conditions such as rosacea, acne vulgaris, and perioral dermatitis.

Precautions for Specific Populations

Pregnant and Lactating Women: Weigh benefits against risks; avoid long-term, large-area use.

Children: Contraindicated in children under 12 years old; adolescents require regular growth monitoring.

Elderly: Use with caution to avoid risks such as osteoporosis associated with long-term use.

Adverse Reaction Monitoring

Local Irritation: Erythema, burning sensation, pruritus (usually mild and reversible).

Skin Atrophy: Prolonged use may lead to skin thinning and deepened wrinkles.

Systemic Absorption Risk: Large-area or occlusive use may trigger Cushing's syndrome (e.g., moon face, hypertension, hyperglycemia).

Infection Risk: Increases the likelihood of bacterial or fungal skin infections, necessitating combination with anti-infective agents.

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