Phloretin

Phloretin is a natural dihydrochalcone found in the peel and root bark of juicy fruit such as apple and pear. It mainly used in cosmetics as a natural skin whitening agent, and food, medicine, health products and other fields.

Phloretin, as flavor raw material, was listed in the FEMA catalog in 2011(FEMA4390), included in the list of China's food additives GB2760 in 2014, code N376; It's also listed in INCI with EC. No 200-488-7.

Structural Formula

Storage

Store in cool & dry place.Do not freeze. Keep away from strong

light and heat

Phloretin, as a natural cosmetic additive, is used in facial mask, skin creams / creams, lotions and serums. Its main functions are:

1. Phloretin or phloretin with ferulic acid and vitamin C can significantly reduce the UV caused by skin persistent melanin and erythema, the melanin control within a reasonable range, there is to prevent hair whitening and

prevent skin cancer;

Example shows

Control sample C measures each sample and sample C is a control formulation containing only the vehicle and no active substance.

Sample A: contains 2% Phloretin, significantly reducing the intensity of UVA-induced erythema.

Sample B: Containing 15% Vitamin C, did not significantly reduce the intensity of erythema caused by UVA.

Sample D: contains 2% phloretin and 0.5% ferulic acid, significantly reducing the intensity of erythema induced by UVA.

Sample E: Contains 15.3% Vitamin C, 0.5% Ferulic Acid, and 1% Vitamin E, significantly reducing protein intensity UVA-induced erythema.

Sample F: Contains 2% Phloretin, 0.5% Ferulic Acid and 15.3% Vitamin C, significantly reducing the intensity of UVA-induced erythema.

2. To promote the absorption of other functional factors, absorb its own weight of 4 to 5 times the moisture, has a strong moisturizing effect;

3. Phloretin can prevent sugar components into the epidermal cells, inhibit the excessive secretion of sebaceous glands, can be used to treat exudative acne;

4. As an antioxidant, phloretin is used in the preparation of topical treatment compositions; used for the treatment of skin disorders such as

Acne Damage, and tones skin conditions.

Representative products:

SKIN CEUTICALS PhloretinCF (Almighty anti-aging cream products): phloretin, a major ingredient, neutralizes the effects of damaging free radicals, improves cell renewal, improves   overall skin tone appearance, forms a protective film on the skin surface, and prevents skin aging and damage.

Phloretin can improve the taste, inhibit bitterness and other discomfort when used in flavors and fragrances. Its main effects are:

1. Synergistic with other trace elements, can effectively inhibit the flavor deterioration;

2. Phloretin with stevia SG95 was used in food and beverage as a taste regulator to mask odor, shorten the linger time of smell, licorice and bitter taste;

The examples show that compared with pomegranate juice of Sample 1 added with 150ppm stevia and Sample 2 added with 35ppm phloretin and 150ppm Stevia, phloretin significantly reduced the sourness and bitterness of the sample while increasing the flavor of the pomegranate juice.

The examples show that the addition of phloretin (30 ppm) to tropical juices has significantly lower bitterness and astringency compared to addition of sucrose (5%) and stevia (25 ppm).

3. By altering the off-flavor sensations of natural high intensity sweeteners, masking other negative flavor profiles such as bitter, licorice, and sour to change the organoleptic properties;

4. As a sweet-smelling aroma, ploretin is used with other sweeteners, fragrances, and non-actives or carriers to prepare an aroma composition for reducing or inhibiting the unpleasant taste impression in the mouth.

Phloretin is rich in biological activity. For health care products in the anti-oxidation, hypoglycemia, blood vessels and other functions, the main effects are:

1. Phloretin can scavenge DPPH radical, ABTS free radical and inhibit lipid peroxidation activity in a concentration-dependent manner.

2. Phloretin can significantly inhibit T lymphocyte proliferation and reduce macrophage NO release, so phloretin has potential anti-inflammatory effect;

3. In terms of immunosuppression, it can increase the fluidity of   the lipid bilayer in the cell and increase the type and activity of drugs that can permeate the cell membrane.

4. Phloretin is a strong anti-oxidant. It can clear free radicals   produced in the body, and inhibit free radical-induced apoptosis at the same time;

5. Phloretin is a potent vasodilator with a non-endothelium-dependent vasodilatory effect.

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