20(S)-Protopanaxadiol

CAS 30636-90-9

Molecular Formula：C30H52O3

Appearance: white powder

Efficacy of Protopanaxadiol

Protopanaxadiol has special efficacy in preventing cancer and aiding post-cancer surgery recovery. As an active ingredient of ginseng, protopanaxadiol also enhances immunity, combats fatigue, and alleviates depression.

The ginsenosides commonly referred to as having antitumor activity are ginsenoside Rg3 and ginsenoside Rh2. Modern research indicates that after oral ingestion, ginsenoside Rg3 and ginsenoside Rh2 undergo comprehensive action by gastric acid, intestinal bacteria, and other bodily mechanisms, ultimately converting into protopanaxadiol.

Recent studies have shown that protopanaxadiol is the actual substance responsible for the anticancer effects of ginsenosides such as Rg3 and Rh2. The amount of protopanaxadiol converted in the body after oral ingestion of ginsenoside Rg3 or Rh2 varies among individuals and is crucial for its anticancer effect.

Protopanaxadiol ≠ ginsenoside. Protopanaxadiol is the core substance that makes ginsenoside products effective, and its effect is far greater than that of ginsenosides.

Ginsenoside Rh2 can be obtained by hydrolyzing the terminal glucose at the 3-position of ginsenoside Rg3, and further hydrolyzing the last glucose at the 3-position of ginsenoside Rh2 ultimately yields [(20S)-Protopanaxadiol].

The advantages of obtaining protopanaxadiol through scientific enrichment, purification, and fermentation of ginseng are as follows:

Zero Burden on the Body, Safer: High-quality ginseng is selected, free from pesticide residues and heavy metals.

Better Antitumor Activity: Ginsenosides belonging to the panaxatriol group are removed, while those in the protopanaxadiol group are retained. Ginsenosides in the panaxatriol group can promote tumor cell growth (commonly known as the component that causes heatiness when consuming ginseng), while those in the protopanaxadiol group can inhibit tumors and prevent their spread, making them the components we truly need.

No Need for In Vivo Conversion, Easy to Absorb: By using fermentation methods to obtain protopanaxadiol, the body directly ingests it, greatly improving bioavailability. Meanwhile, it avoids the instability of effects caused by varying conversion rates of directly ingested ginsenoside protopanaxadiol (such as ginsenoside Rg3 and Rh2) in individuals with different constitutions.

Studies have shown that among the currently available ginsenoside protopanaxadiol group products, ginsenoside Rh2 has the highest bioavailability, approximately 16%. If we directly ingest protopanaxadiol, bypassing the conversion process of Rh2 to protopanaxadiol in the human body, and considering factors such as the bioavailability of protopanaxadiol, the effect of directly ingesting protopanaxadiol is more than 8 times that of ingesting ginsenoside Rh2.

In 1983, Japanese scholar Kitagawa Koichi first isolated 20(R)-ginsenoside Rg3 and 20(S)-ginsenoside Rg3 from Korean red ginseng. Ginsenoside Rh2 is a degradation product of 20(R)-ginsenoside Rg3. Studies have shown that the unique ginsenoside Rh2 in red ginseng is almost absent in white ginseng, suggesting that ginsenosides Rg3 and Rh2 are secondary saponins formed during the process of steaming white ginseng into red ginseng. However, the content of Rh2 in red ginseng is also very low, with an extraction yield of less than one in a hundred thousand, meaning that at most 1mg can be obtained from 100g of red ginseng; the content of Rg3 in white ginseng generally does not exceed two in ten thousand. Assuming that all Rh2 converts to protopanaxadiol, approximately 10 grams of ginseng would be equivalent to 10mg of protopanaxadiol.

The efficacy of protopanaxadiol includes:

Regulating the cell proliferation cycle, mainly targeting and killing tumor cells in the proliferative phase.

Inducing tumor cell apoptosis without causing inflammation.

Assisting chemotherapy by enhancing sensitivity to chemotherapy drugs.

Reversing tumor drug resistance and enhancing the efficacy of traditional chemotherapy.

Reducing the toxic and side effects of chemotherapy and increasing white blood cell count.

Inducing differentiation of tumor cells into normal cells.

Preventing tumor metastasis.

Preventing tumor recurrence during the recovery phase.

Balancing the immune system and preventing carcinogenesis.

Multiple anti-fatigue effects, rapidly recovering from physiological or psychologically induced fatigue, effectively alleviating symptoms such as dizziness and drowsiness, increasing fatty acid consumption for energy production, boosting spirits, improving endurance, and enhancing physical constitution.

Red Ginseng: Red ginseng is processed from ginseng through soaking, cleaning, sorting, steaming, drying, and other processes. It has a brownish-red, translucent appearance with large longitudinal wrinkles, inconspicuous ring patterns, marks of branch roots, and a yellowish-brown upper part of the rhizome. Red ginseng is used for conditions such as severe debility with collapse tendency, cold limbs and feeble pulses, metrorrhagia and metrostaxis, heart failure, and cardiogenic shock. Red ginseng is a processed form of ginseng with effects of replenishing qi, restoring pulse and preventing collapse, and invigorating qi to arrest bleeding.

White Ginseng: White ginseng is a traditional Chinese medicine processed from ginseng through special methods. It differs from red ginseng and refers to various processed products of ginseng other than red ginseng, such as sun-dried ginseng, white sugar ginseng, and dried white ginseng, collectively known as white ginseng. Ginsenosides Rg3 and Rh2 were first discovered in red ginseng. Studies have shown that the unique ginsenoside Rh2 in red ginseng is almost absent in white ginseng, indicating that ginsenosides Rg3 and Rh2 are secondary saponins formed during the fermentation process of steaming white ginseng into red ginseng. Protopanaxadiol is a further converted product of ginsenoside Rh2.

Suitable Populations for Protopanaxadiol:

Patients who have just been diagnosed with cancer but for whom a specific treatment plan has not yet been determined. Taking protopanaxadiol along with medication can control disease progression and prevent tumor metastasis and spread.

Patients before surgery can take it to shrink the tumor, reduce the surgical scope, and increase the success rate of surgery.

Post-surgery patients can take it to eliminate residual cancer cells, prevent recurrence and metastasis, accelerate wound healing, reduce inflammation and pain, prevent infection, and avoid complications.

Patients undergoing radiotherapy and chemotherapy can take it to eliminate toxic and side effects, enhance drug sensitivity, and improve efficacy.

Patients with acute, severe, or advanced cancer who are physically weak can take it to enhance their resistance to disease, improve their quality of life, and extend their lifespan.

Cancer patients in the recovery phase can take it regularly to effectively eliminate residual tumor cells and microlesions in the body, enhance their constitution, consolidate treatment efficacy, and prevent recurrence and metastasis.

Individuals with a family history of cancer.

Individuals with weakened immunity, high work stress, no exercise habits, and those in a subhealthy state.

Protopanaxadiol can be used by various populations. Nowadays, we often emphasize the concept of "preventive treatment of disease" because once a tumor occurs, it is difficult to cure. Therefore, preventing tumors is the best measure for treating them. Only by eradicating the disease in its early stages can we permanently eliminate potential problems. From when a tumor can first be detected through a physical examination to its advanced stage, it may only take a few months. With an annual physical examination frequency, taking protopanaxadiol regularly can significantly delay the risk of tumor development!

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